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buy apple developer account :‘Pressing need’ for new medicines to treat antibiotic-resistant gonorrhoea

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,The bacteria that cause gonorrhoea evolve to resist every new class of antibiotics developed to treat the infection. (iStock) Tweet Facebook Mail There is a “pressing need” for new medicines to treat gonorrhoea as antibiotic-resistant cases of the common sexually-transmitted infection are on the rise, making it harder to treat, the World Health Organisation has warned. At least three people worldwide are infected with an untreatable “superbug” strain of the infection as resistance to older and cheaper antibiotics spreads, and WHO experts said yesterday this may just be the “tip of the iceberg”. “The bacteria that cause gonorrhoea are particularly smart. Every time we use a new class of antibiotics to treat the infection, the bacteria evolve to resist them,” Dr Teodora Wi, WHO medical officer in human reproduction, said. The Geneva-based UN health agency estimates 78 million people are diagnosed with the disease that can infect the genitals, rectum and throat, each year. Complications disproportionally affect women through cases of pelvic inflammatory disease, ectopic pregnancy and infertility as well as an increased risk of HIV Aids. In Australia, the number of Queenslanders diagnosed with gonorrhoea rose by 321 cases this year, compared to the same time last year. According to the WHO, decreasing condom use, increased urbanisation and travel as well as poor infection detection rates and inadequate or failed treatment point to the increase. RelatedRush to publish COVID-19 research saw errors in top medical journals triple, study findsNew health alert in South Australia after positive COVID-19 case breached quarantineTwo new coronavirus cases reported in South AustraliaDr Wi said one study published in the journal PLOS Medical documented the three specific cases of gonorrhoea, in Japan, France and Spain, of which no known antibiotic has proven effective. "These are cases that can infect others. It can be transmitted," she told reporters.“These cases may just be the tip of the iceberg since systems to diagnose and report untreatable infections are lacking in lower-income countries where gonorrhoea is actually more common.” The WHO's program for monitoring trends in drug-resistant gonorrhoea found in a study that from 2009 to 2014 there was widespread resistance to the first-line medicine ciprofloxacin, increasing resistance to another antibiotic drugs called azithromycin, and the emergence of resistance to last-resort treatments known as extended-spectrum cephalosporins (ESCs).In most countries, it said, ESCs are now the only single antibiotics that remain effective for treating gonorrhoea. Yet resistance to them has already been reported in 50 countries.Decreasing condom use has been attributed to the rise of antibiotic-resistant cases of the infection. (iStock) (iStock/Getty Images)Manica Balasegaram, director of the Global Antibiotic Research and Development Partnership, said the situation was "grim" and there was a "pressing need" for new medicines.And the trajectory for new drugs to treat the infection is “relatively empty” with only three new candidate drugs in various stages of clinical development. But developing new antibiotics is unattractive for pharmaceutical companies, with treatments only being taken for short periods and becoming less effective as resistance develops. "To address the pressing need for new treatments for gonorrhoea, we urgently need to seize the opportunities we have with existing drugs and candidates in the pipeline,” Dr Balasegaram said. “In the short term, we aim to accelerate the development and introduction of at least one of these pipeline drugs, and will evaluate the possible development of combination treatments for public health use."Any new treatment developed should be accessible to everyone who needs it, while ensuring it’s used appropriately, so that drug resistance is slowed as much as possible."
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